Personalis at Immuno UK: October 13-14, 2021

Presentation

Erin Newburn, PhD

Erin Newburn, PhD
Director, Field Applications Scientist
Personalis, Inc.

Wednesday, OCT 13 | 2:45 PM BST

Maximizing Immuno-Oncology Biomarker Discovery with the Universal Cancer Immunogenomics Platform ImmunoID NeXT

  • To enable the identification of composite biomarkers that combine tumor- and immune-related information from both DNA and RNA, we have developed the Personalis NeXT platform
  • By utilizing the expansive feature set, individual analytes can be combined to construct composite biomarker scores that correlate with immunotherapy response.
  • In a cohort of 51 late-stage melanoma patients, the integration of neoantigen burden, HLA LOH, and APM mutational data formed a neoantigen-based composite neoantigen (NEOPS) that more accurately predicted response to checkpoint blockade than other markers such as TMB.
  • The platform has been analytically validated and optimized for use with limited FFPE tissue samples, making it ideal for both research and clinical applications.

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