NGS-based Tumor Profiling: Lab, Clinic & Patient Perspectives
This presentation covers comprehensive tumor characterization solutions for clinical trials, cancer research and immune-oncology, including: specific challenges in sequencing and analyzing tumors for neoantigen identification; key differentiators of the ACE IThree speakers from NSGC’s Annual Education Conference 2016 present key challenges associated with NGS-based tumor profiling. Learning objectives include:
1. Define the conditions and logistical considerations for somatic tumor testing and summarize what the results of somatic tumor testing mean for your patients
- The goal of somatic tumor testing
- Sample types required
- Reasons for testing
- Published guidelines for testing
2. Examine some of the challenges associated with somatic tumor testing including the significance and ethical considerations regarding pathogenic germline variants
- FFPE samples
- Tumor purity & heterogeneity
- Evaluating clinically relevant vs. VUS results
- How germline pathogenic variants are detected/reported
- Ethical considerations regarding pathogenic germline variants