Figure 4: ImmunogenomicsID delivers biological insights into each of the highlighted biomarkers and functional areas of tumor biology.
ImmunogenomicsID provides an overview of TME-related biomarkers and critical genes that are involved in – or highly impact – key oncology functional groups including HLA (LOH and somatic mutations) and other antigen processing machinery (APM), DNA repair and replication, immune checkpoint modulation, tumor associated antigens (TAAs), adaptive and innate immune response, cytokines and chemokines, and cytotoxicity. Utilizing an industry-leading algorithm, ImmunogenoicsID also provides a characterization of MSI within a tumor sample, highlighting the stability status of five canonical loci, as well as the proportion of all microsatellite loci that are found to be unstable.
Additionally, ImmunogenomicsID — via the specific targeting of viral genomes in both DNA and RNA — reports out on the presence (or absence) of viruses that are known to contribute to oncogenesis in a broad variety of cancer types. These oncoviruses include HPV, HBV, HCV, EBV, KSHV, MCH, and HTLV, and their associated genotypes and subtypes.