An analytical module of the ImmunoID NeXT PlatformTM
Comprehensive Immunogenomic Characterization
ImmunogenomicsIDTM, an analytical module of the ImmunoID NeXT Platform, characterizes critical areas of tumor and immune biology such as the antigen processing machinery (APM), human leukocyte antigens (HLA), checkpoint modulation, tumor escape mechanisms, the adaptive and innate immune response, while also providing a readout on the microsatellite instability (MSI) profile of the tumor and the presence or absence of oncogenic viruses. As part of ImmunoID NeXT, ImmunogenomicsID leverages exome-scale DNA and RNA sequencing data from a paired tumor and normal sample to generate a comprehensive immunogenomic profile of the tumor and its microenvironment. This includes tumor mutational burden (TMB) and reporting on gene-level expression (TPM), variant type (SNVs, indels, fusions), variant expression, DNA and RNA allelic fraction (5%), as well as variant effect impact.