2018 AACR: Deconvolution of diverse immune cell populations within tumors using ACE Transcriptome Comprehensive tumor immuno-genomic characterization is becoming an important tool for identifying new biomarkers correlated with patient response to immunotherapy. Both the abundance and composition of tumor-infiltrating immune cells have been associated with tumor progression and patient outcome. There is interest in [...]
2017 AACR: Accurately Identifying Neoantigens Utilizing Both DNA and RNA Somatic Variants in an Enhanced Platform
The identification of neoantigens is a crucial step in the development of neoantigen-based personalized cancer vaccines and other immunotherapies.
2017 AACR: Supporting Neoantigen Identification for Personalized Cancer Vaccines Through Analytical Validation of an Augmented Content Enhanced (ACE) Exome
The identification of neoantigens has become a critical step in the development of neoantigenbased personalized cancer vaccines and other immunotherapy applications.
2017 AACR: Comparative Analysis Of Multiple Copy Number Alteration Tools In The Detection Of Amplifications And Deletions On Both Whole-exome And Targeted NGS Panel Platforms
Somatic copy number variations, or CNVs, are frequent occurrences in the tumor landscape and thedetection of these events remains a challenge.
2017 AACR: Supporting Neoantigen Identification for Personalized Cancer Vaccines Through Analytical Validation of an Augmented Content Enhanced (ACE) Transcriptome
Neoantigen identification, or the detection of tumor-specific variants, is a critical step inpersonalized cancer vaccine development.
2017 ASCO: Validation of an Expanded Neoantigen Identication Platform for Therapeutic and Diagnostic Use in Immuno-oncology
Neoantigen identiﬁcation is increasingly critical for clinical immuno-oncology applications including predicting immunotherapy response and neoantigen-based personalized cancer vaccines.
2016 AACR-JCA: When Detecting Somatic Variants in Cancer Genomes, Is it Necessary to Sequence Matched Normal Tissue?
Next-generation sequencing is commonly used to identify somatic variation in cancer.
2016 USCAP: Effects of formalin fixation variables on DNA integrity for genomic applications in cancer
Formalin fixation and paraffin embedding (FFPE) is routinely used for tissue preservation.
2016 USCAP: Validation of a Clinical 1400-Gene Assay for Genomic Profiling of Cancer from DNA and RNA
Genomic assays are increasingly used in oncology to guide clinical management and assess tumor responsiveness to novel therapeutics.
Whole-exome sequencing is a cost-effective way of detecting clinicallyrelevant small variants with high sensitivity.