Library Archives - Personalis

7 Jul, 2020

2020 AACR: Enhanced Whole Exome Profiling of Tumor Circulating Cell-Free DNA Enables Sensitive Assessment of Tumor Mutations

2020 AACR: Enhanced Whole Exome Profiling of Tumor Circulating Cell-Free DNA Enables Sensitive Assessment of Tumor Mutations An increasing number of studies have demonstrated the potential use of circulating cell-free DNA (cfDNA) for diagnosis, prognosis, and disease progression monitoring. However, many of these studies utilize assays covering a limited set of well known genes, [...]

7 Jul, 2020

2020 AACR: Improved Tumor-Only Somatic Variant Calling Using a Gradient Boosted Machine Learning Algorithm

2020 AACR: Improved Tumor-Only Somatic Variant Calling Using a Gradient Boosted Machine Learning Algorithm Accurate identification of somatic variants in a tumor sample is often accomplished by utilizing a paired normal tissue sample from the same patient to enable the separation of private germline mutations from somatic variants. However, a paired normal sample is [...]

7 Jul, 2020

2020 AACR: A diagnostic platform for precision cancer therapy enabling composite biomarkers by combining tumor and immune features from an enhanced exome and transcriptome

2020 AACR: A diagnostic platform for precision cancer therapy enabling composite biomarkers by combining tumor and immune features from an enhanced exome and transcriptome While the success of immune checkpoint blockade (ICB) has been hugely promising, it’s increasingly apparent that predicting response to immunotherapies requires a more comprehensive approach to tumor immunogenomic profiling. There [...]

7 Jul, 2020

2020 AACR: A Pan-Cancer Characterization of Both the Tumor and Micro Environment Highlights the Importance of an Integrated Approach for Immuno-Oncology

2020 AACR: A Pan-Cancer Characterization of Both the Tumor and Micro Environment Highlights the Importance of an Integrated Approach for Immuno-Oncology A better understanding of the characteristics of cancer across different indications is required to drive the development of personalized treatments, inform therapy decisions, and improve outcomes. Integrating data from the tumor and the [...]

7 Jul, 2020

2020 AACR: Composite neoantigen score is more strongly associated with therapeutic response than tumor mutational burden in a cohort of late-stage anti-PD-1-treated melanoma patients

2020 AACR: Composite neoantigen score is more strongly associated with therapeutic response than tumor mutational burden in a cohort of late-stage anti-PD-1-treated melanoma patients Checkpoint inhibitor therapy has demonstrated meaningful, if varied, antitumor activity, with patient response influenced by a variety of biological factors, including complex interactions between the tumor and immune system. Thus, [...]

7 Jul, 2020

2020 AACR: Quantification of tumor-infiltrating immune cell populations with an augmented transcriptome

2020 AACR: Quantification of tumor-infiltrating immune cell populations with an augmented transcriptome Comprehensive characterization of the tumor and tumor microenvironment (TME) can improve our understanding of tumor progression and treatment outcomes. In particular, quantification of the immune infiltrate has the potential to inform mechanisms of immune escape and predict response to therapy. Standard experimental [...]

7 Jul, 2020

2020 AACR: Precision neoantigen discovery using a pan-predictive machine learning model integrated into ImmunoID NeXT Platform®

2020 AACR: Precision neoantigen discovery using a pan-predictive machine learning model integrated into ImmunoID NeXT Platform® Technologies for neoantigen discovery are critical for developing personalized cancer vaccines and neoantigen-based biomarkers. Precision neoantigen discovery entails comprehensive detection of tumor-specific genomic variants and accurate prediction of MHC presentation of epitopes originating from such variants. Our ImmunoID [...]

7 Jul, 2020

2020 AACR: Sensitive HLA loss of heterozygosity detection reveals allele-specific neoantigen expansion as resistance mechanism to anti-PD-1 therapy

2020 AACR: Sensitive HLA loss of heterozygosity detection reveals allele-specific neoantigen expansion as resistance Loss of heterozygosity (LOH) in the HLA locus is increasingly being recognized as an important mechanism of immune escape and a proposed biomarker for immunotherapy response. Neoantigens that bind to a deleted HLA allele will no longer be presented to [...]

7 Jul, 2020

2020 ASCO: Exome scale liquid biopsy characterization of putative neoantigens and genomic biomarkers pre- and post anti-PD-1 therapy in squamous cell carcinoma of the head and neck.

2020 ASCO: Exome scale liquid biopsy characterization of putative neoantigens and genomic biomarkers pre- and post anti-PD-1 therapy in squamous cell carcinoma of the head and neck. Background: The reduced scope, and number of genes profiled by typical liquid biopsy panels can result in missed biomarkers including neoantigens, which may change with treatment, as [...]

7 Jul, 2020

2020 ASCO: Validation of an exome and transcriptome based diagnostic platform enabling clinical cancer therapy selection and emerging composite biomarkers for immunotherapy

2020 ASCO: Validation of an exome and transcriptome based diagnostic platform enabling clinical cancer therapy selection and emerging composite biomarkers for immunotherapy Authors: Juan-Sebstian Saldivar, Jason Harris, Sejal Desai, Erin Ayash, Prateek Tandon, Twinkal Marfatia, Robert Power, Massimo Morra, Manju Chinnappa, Michael James Clark, Rena McClory, Richard Chen; Personalis, Inc., Menlo [...]

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