The power of gene and variant-level expression in immuno-oncology biomarker discovery
Recent advancements in RNASeq technology have revolutionized the search for the genes and gene expression signatures that determine immunotherapy response by providing a high throughput method of comprehensively examining changes in these functional elements.READ MORE
ACE ImmunoID Platform for reverse translation
Laboratory models have been central to the fast evolving field of immuno-oncology and immunotherapy drug development. We continue to learn from ...READ MORE
Ethnic disparities in precision genomics
The premise of the right drug for the right patient at the right time is critical for indications from cardiovascular and infectious disease to the latest immuno-oncology strategies. It’s imperative to comprehend which patient will derive benefit from ...READ MORE
Refining neoantigen load
Tumor mutational burden (TMB) has now been established as a positive predictive biomarker of response to immune checkpoint inhibitors with more studies demonstrating correlations between the overall mutational landscape and clinical benefit ...READ MORE
Overcoming the obstacles of neoantigen identification
Neoantigen-based cancer vaccines represent new, truly personalized therapeutic approaches to treating cancer.READ MORE