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So far mckinleymedia has created 229 blog entries.
15 Nov, 2021

2021 SITC: Extensively validated HLA LOH algorithm demonstrates an association between HLA LOH and genomic instability

2021 SITC: Extensively validated HLA LOH algorithm demonstrates an association between HLA LOH and genomic instability Background Human Leukocyte Antigen (HLA) genes are critical for the presentation of neoantigens to the immune system by cancer cells. Deletion of HLA alleles, known as HLA loss of heterozygosity (LOH), has been highlighted as a key immune [...]

15 Nov, 2021

2021 SITC: Exome-scale liquid biopsy characterization of emerging immune resistance mechanisms in treatment-resistant GIST

2021 SITC: Exome-scale liquid biopsy characterization of emerging immune resistance mechanisms in treatment-resistant GIST Background Metastatic gastrointestinal stromal tumors (GIST) are lethal tumors of the GI tract characterized by gain of function mutations in KIT or PDGFRɑ. Transient first-line control is achieved through the inhibition of tyrosine kinase signaling using the KIT inhibitor imatinib, [...]

2 Nov, 2021

InfiltrateID

InfiltrateID™ Quantification of the Immunocellular Content in the Tumor Microenvironment The emergence and success of immuno-oncology drugs in the treatment of several cancer types has transformed clinical practice. However, many patients do not respond to these drugs, compelling researchers and clinicians to broaden their search for biomarkers that can better [...]

26 Oct, 2021

Precision Neoantigen Discovery Using Large-scale Immunopeptidomes and Composite Modeling of MHC Peptide Presentation

Precision Neoantigen Discovery Using Large-scale Immunopeptidomes and Composite Modeling of MHC Peptide Presentation Immunopeptidomics Special Issue of the journal Molecular & Cellular Proteomics January 2021 Volume 20, 100111 The Personalis authors created Systematic HLA Epitope Ranking Pan Algorithm (SHERPA™), a novel pan-allelic machine learning algorithm for predicting MHC-peptide binding and [...]

2 Aug, 2021

Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance Mechanisms

Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance Mechanisms Clinical Cancer Research August 2021 Volume 27, Issue 15 This work evaluates the predictive strength of a composite biomarker, neoantigen presentation score (NEOPS), in a cohort of patients with late-stage melanoma. NEOPS incorporates damaging events [...]

24 Jun, 2021

Parker Institute Case Study: The PRINCE Trial

2021 NeXT Level Biomarkers Symposium: Parker Institute Case Study: The PRINCE Trial Theresa LaVallee, PhD Vice President, Translation Medicine and Regulatory Affairs Parker Institute for Cancer Immunotherapy Lee McDaniel, MD, MSE Sr. Bioinformatics Scientist Personalis, Inc.

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