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So far mckinleymedia has created 216 blog entries.
22 May, 2021

2021 AACR: Accurate modeling of antigen processing and MHC peptide presentation using large-scale immunopeptidomes and a novel machine learning framework

2021 AACR: Accurate modeling of antigen processing and MHC peptide presentation using large-scale immunopeptidomes and a novel machine learning framework Neoantigens, which are antigens specific to cancer cells, can be harnessed to develop personalized cancer vaccines and prognostic biomarkers for checkpoint blockade inhibition. Next generation sequencing technologies have enabled comprehensive profiling of putative neoantigens [...]

22 May, 2021

2021 AACR: Pan-cancer survey of HLA loss of heterozygosity using a robustly validated NGS based machine learning algorithm

2021 AACR: Pan-cancer survey of HLA loss of heterozygosity using a robustly validated NGS based machine learning algorithm HLA loss of heterozygosity (LOH) is increasingly being recognized as an important immune escape mechanism in response to checkpoint inhibitor therapy. HLA LOH reduces the repertoire of neoantigens displayed on the cell surface of cancer cells, [...]

22 May, 2021

2021 AACR: Pan-cancer shedding patterns of tumor circulating cell-free DNA

2021 AACR: Pan-cancer shedding patterns of tumor circulating cell-free DNA Tumor circulating cell-free DNA (ctDNA) comprises DNA molecules cast from tumors that reach and circulate in a patient's bloodstream. Given its non-invasive nature, the liquid biopsy of ctDNA has remarkable potential for diagnosis, prognosis, disease progression tracking, and treatment monitoring. Nonetheless, little is known [...]

22 May, 2021

2021 AACR: Profiling tumor-infiltrating immune cells using an augmented transcriptome

2021 AACR: Profiling tumor-infiltrating immune cells using an augmented transcriptome Due to the complexity of tumor-immune interactions, comprehensive profiling of both the tumor and tumor microenvironment (TME) can help further our understanding of tumor progression and response to treatment. One significant application is quantification of the immune infiltrate, which has the potential to characterize [...]

12 May, 2021

Scaling

Our CAP-accredited, CLIA-certified laboratory operates 7 days a week and is one of the largest sequencing centers in the U.S. today with a capacity to sequence >100,000 human whole genome/exome scale samples per year. Our lab boasts the latest in technology to ensure high quality data delivery and rapid timelines, including: [...]

30 Nov, 2020

2020 EACR Liquid Biopsies Sponsored Symposia

2020 EACR Liquid Biopsies Sponsored Symposia NeXT Liquid Biopsy, A High Performance, Exome-Wide Liquid Biopsy Assay to Study Tumor Dynamics Erin Newburn, PhD Associate Director, Field Applications Scientist Dan Norton, MBA Sr. Product Manager NeXT Liquid Biopsy™, a first-of-its-kind, high-performance exome-wide [...]

24 Nov, 2020

2020 SITC: Orthogonally and functionally validated algorithm for detecting HLA loss of heterozygosity

2020 SITC: Orthogonally and functionally validated algorithm for detecting HLA loss of heterozygosity T cells can inhibit tumor growth and progression by recognizing major histocompatibility complex class I (MHC-I) -bound peptides derived from antigens that are mutated, inappropriately expressed, or overexpressed in the tumor cells (vs. healthy cells). There are many mechanisms by which [...]

24 Nov, 2020

2020 SITC: B-cell receptor heavy chain repertoire profiling using an augmented transcriptome

2020 SITC: B-cell receptor heavy chain repertoire profiling using an augmented transcriptome Comprehensively profiling the tumor and tumor microenvironment (TME) can help provide a more complete view of the complex interactions between the tumor and immune system, potentially furthering our understanding of tumor progression and response to treatment. We have developed an augmented, immuno-oncology-optimized exome/transcriptome [...]

24 Nov, 2020

2020 SITC: Profiling tumor circulating cell-free DNA with an enhanced whole-exome to enable sensitive assessment of somatic mutations

2020 SITC: Profiling tumor circulating cell-free DNA with an enhanced whole-exome to enable sensitive assessment of somatic mutations The analysis of tumors using circulating cell-free DNA (cfDNA) is beginning to transform cancer diagnosis, prognosis, response to therapy and to enable disease progression monitoring. Most cfDNA assays are centered around the identification of therapeutically actionable [...]

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