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So far mckinleymedia has created 223 blog entries.
17 Apr, 2020

Stephen Moore, JD

Stephen Moore joined Personalis as General Counsel in April 2020, with more than twenty years in-house legal experience at advanced genomics companies. Prior to joining Personalis, he was General Counsel at Pacific Biosciences, a publicly listed company and pioneer in the field of single molecule, long read DNA sequencing, where he worked for over a [...]

13 Mar, 2020

Whole Genome Sequencing

In recent years, the declining cost of NGS has resulted in the increased use of broad genomic characterization approaches, including whole genome sequencing (WGS), for various research applications. This cost reduction has coincided with researchers’ need for more comprehensive molecular information in the disease areas of cardiology, endocrinology, rare disease, autoimmunity, and ever-increasingly, cancer. WGS [...]

13 Mar, 2020

miRNA Sequencing

Micro RNAs (miRNAs) are a small non-coding type of RNA molecule (18-40 nucleotides in length) that play a functional role in the regulation of RNA silencing and post-transcriptional gene expression. miRNA-Seq enables the investigation of the function of small RNAs and the evaluation of regulatory networks of miRNAs and their target genes. Technical Details Sequencing [...]

13 Mar, 2020

Targeted Cancer Panels

ACE Extended Cancer Panel for DNA The ACE Extended Cancer Panel covers a core set of >1,400 cancer-related genes, including clinically-actionable* genes as well as genes that have been identified in the literature as having a role to play in tumorigenesis. The panel provides deep and uniform coverage of genes associated with functional pathways that are [...]

13 Mar, 2020

Transcriptome Sequencing

ACE Research Transcriptome The same accuracy and coverage enhancements of the ACE Research Exome (see above) are also incorporated into RNA analysis using our unique ACE Research Transcriptome enrichment protocol. Many clinical studies depend on tissue archives that have been fixed using formalin-fixed, paraffin-embedded (FFPE) procedures. This preservation process makes it difficult to obtain a [...]

13 Mar, 2020

Exome Sequencing

ACE Research Exome Using our patented Accuracy and Content Enhanced (ACE) Technology, the ACE Research Exome outperforms conventional exome assays by augmenting coverage across intronic and difficult-to-sequence regions (including regions of high-GC content) of >8,000 biomedically-important genes, including >1,400 cancer-related genes. The application of this technology ensures the delivery of more complete and uniform coverage of [...]

29 Jan, 2020

Personalis NeXT Dx™ Test Data Sheet

Personalis NeXT Dx™ Test Increasingly, oncologists and pathologists are utilizing information on genomic alterations in solid tumors, such as lung, colon, breast, melanoma, and prostate cancers, to help guide and optimize therapeutic options for patients including enrolling into cancer clinical trials. The Personalis NeXT Dx™ Test provides clinicians with a comprehensive [...]

25 Nov, 2019

2019 AACR-NCI-EORTC (ANE) Molecular Targets: A comprehensive, highly accurate genomics platform for precision immunotherapy: Simultaneously characterize tumors and the TME from a single FFPE sample

2019 AACR-NCI-EORTC (ANE) Molecular Targets: A comprehensive, highly accurate genomics platform for precision immunotherapy: Simultaneously characterize tumors and the TME from a single FFPE sample While the success of checkpoint blockade has been hugely promising, it’s increasingly apparent that predicting response to immunotherapies and developing new ones requires a more comprehensive approach to tumor [...]

25 Nov, 2019

2019 SITC: Comprehensive and accurate prediction of presented neoantigens using ImmunoID NeXT and advanced machine learning algorithms

2019 SITC: Comprehensive and accurate prediction of presented neoantigens using ImmunoID NeXT and advanced machine learning algorithms Comprehensive detection of potential neoantigens and accurate prediction of their MHC presentation are critical prerequisites for selecting neoepitopes that can be used for creating personalized cancer vaccines. However, prediction models developed using in-vitro MHC-peptide purification followed by [...]