Powered by our ACE Technology, our DNA Assays provide more uniform coverage at high depths than standard assays. Specifically, our ACE-enabled assays outperform conventional exome assays by enhances coverage across coding regions and supplementing more complex areas in the genomic architecture such as GC-rich content. The Personalis solution provides targeted sequencing to augment coverage gaps [...]
Our patented ACE™ (Accuracy and Content Enhanced) Technology is the foundation of ImmunoID NeXT and all proprietary Personalis products. ACE improves processes from nucleic acid preparation, to sequencing, to analytics for superior sequencing results. Nucleic Acid Extraction and Sample Preparation Personalis has developed protocols to overcome the challenges of working with difficult samples including FFPE, [...]
HLA binding is currently the most well-established criteria for ranking neoantigen candidates. Recent advances in training data generated from mass spectrometry provide a larger dataset of peptide binders and non-binders for individual HLA alleles. This new binding data takes two important additional components into consideration: cleavage and transportation, which are critically important for presentation assessment. [...]
NeoantigenID Technologies for neoantigen discovery are critical for the development of personalized cancer therapies and neoantigen-based biomarkers. Precision neoantigen discovery entails comprehensive detection of tumor-specific genomic variants and accurate prediction of MHC presentation of epitopes originating from such variants. Our ImmunoID NeXT Platform® enables a comprehensive survey of putative neoantigens by combining highly sensitive exome- [...]
Deep Sequencing ~2,000X mean coverage across the entire ~20,000-gene DNA footprint, as well as boosted ~5,000 mean coverage across ~247 cancer-related genes to deliver enhanced sensitivity. Augmented Coverage NeXT Liquid Biopsy utilizes our proprietary ACE Technology to provide augmented coverage of difficult-to-sequence gene regions across the entire ~20,000-gene footprint. Advanced Error Suppression Our robust variant [...]
NeXT Liquid Biopsy™ It’s Time to Think About More. High-Performance Whole Exome Sequencing from Plasma. Highlights Comprehensively profile the tumor, exome-wide Combined with ImmunoID NeXT™, assess tumor heterogeneity, monitor response to therapy, and interrogate mechanisms of resistance Profile with ImmunoID NeXT, Monitor with NeXT Liquid Biopsy Leverage somatic variant [...]
Stephen Moore joined Personalis as General Counsel in April 2020, with more than twenty years in-house legal experience at advanced genomics companies. Prior to joining Personalis, he was General Counsel at Pacific Biosciences, a publicly listed company and pioneer in the field of single molecule, long read DNA sequencing, where he worked for over a [...]
In recent years, the declining cost of NGS has resulted in the increased use of broad genomic characterization approaches, including whole genome sequencing (WGS), for various research applications. This cost reduction has coincided with researchers’ need for more comprehensive molecular information in the disease areas of cardiology, endocrinology, rare disease, autoimmunity, and ever-increasingly, cancer. WGS [...]
Micro RNAs (miRNAs) are a small non-coding type of RNA molecule (18-40 nucleotides in length) that play a functional role in the regulation of RNA silencing and post-transcriptional gene expression. miRNA-Seq enables the investigation of the function of small RNAs and the evaluation of regulatory networks of miRNAs and their target genes. Technical Details Sequencing [...]
ACE Extended Cancer Panel for DNA The ACE Extended Cancer Panel covers a core set of >1,400 cancer-related genes, including clinically-actionable* genes as well as genes that have been identified in the literature as having a role to play in tumorigenesis. The panel provides deep and uniform coverage of genes associated with functional pathways that are [...]
