jhavlek

2022 AACR Poster #146: Transcriptome augmentation provides accurate and sensitive quantification of genes associated with the tumor microenvironment Overview Tumors harbor a complex and dynamic ecosystem of malignant, immune, and stromal cells. While malignant cells dictate much of the tumor biology, there is evidence that the tumor microenvironment (TME) also plays a significant role [...]

2022 SITC Poster #51: A combination of antigen presentation and T-cell recognition features improves neoantigen immunogenicity predictions Overview Tumor neoantigen burden outperforms tumor mutational burden (TMB) in prediction of patient response to immune checkpoint blockade (ICB) therapy by better capturing the biological mechanism underlying response [1]. However, immune recognition of neoantigens by T-cells requires [...]

2022 SITC Poster #119: Sensitive prediction of immunotherapy response by integrating immune infiltration and neoantigen presentation score in late-stage melanoma Overview Single-modality biomarkers such as tumor mutational burden (TMB) often fail to reliably predict response to immune checkpoint blockade (ICB), likely due to incomplete characterization of the complex tumor-immune interactions that influence treatment efficacy. We [...]