2018 SITC: More Sensitive Identification of T-cell Receptor Beta Arrangements with an Augmented Transcriptome Method

With the increase in development and use of immunotherapies, there is also an increasing need for comprehensive immuno-genomic profiling of tumors to identify new potential biomarkers. This includes profiling of the T-cell receptor (TCR), which has traditionally not been feasible with an exome/transcriptome scale platform. To solve this problem, we have developed comprehensive TCR & BCR profiling as part of the ImmunoID NeXT platform. Here, we show how this can be applied to understand the diversity and activity of the adaptive immune system.