2015 ASHG: Comprehensive Genomic Characterization of Three Spatially and Temporally Distinct Tumors from Different Organs in a Single Patient Exhibiting both BRCA2 and VHL Germline Mutations

Inherited genetic mutations have been strongly associated with heightened risk for a broad range of cancer subtypes. Over the last two decades, large efforts have focused on recognizing cancer driver genes and better understanding their role in cancer progression, resulting in identification and characterization of important drivers. In very rare cases, a single individual has germline mutations in more than one of these cancer driver genes.