## 2014 AACR: Creating and Accurately Interpreting Clinical-grade Cancer Exomes with ACE Exome

Exome sequencing is increasingly utilized to diagnose and direct treatment for cancer patients. However, there are many barriers to sequencing cancer exomes in an accurate and comprehensive way to assess all crucial cancer mutations. We have developed a comprehensive approach combining the Personalis ACE Exome™ and cancer analyses to improve accuracy and completeness of sequencing, call structural variants from exome, and comprehensively annotate cancer samples.