ACE Services for

Clinical Research

The highest level of gene finishing and detection sensitivity

ACE Services for Clinical Research 2016-12-06T14:00:42+00:00

ACE Exome™ for Clinical Research

Designed to provide comprehensive information for every sample

The Most Optimized Exome PlatformAvailable for Clinical Researchthmb_clinical_research

The ACE Exome for Clinical Research augments a standard exome by supplementing coverage of over 8,000 biomedically important genes, enabling variants to be identified more accurately and reliably in these regions which may be completely missed by a standard, or even clinically focused exome. The ACE Exome also provides coverage of regions outside the exome including regulatory regions and functionally important intergenic and intronic regions.

This highly accurate and sensitive assay is the most optimized exome platform available for clinical research. Sequence data is aligned and variants are called and annotated using the Personalis advanced variant discovery and annotation engine. Read more about the Personalis ACE Platform.

Comprehensive content set for a broad biomedical footprint

Key Features

  • Whole exome plus augmented coverage of over 8,000 biomedically important genes
  • Comprehensive, curated clinically-focused content set
  • Highly accurate alignment and variant calling
  • Enhanced coverage of difficult-to-sequence regions, such as high GC
  • Minimum data guarantee for every sample
  • Extensive variant annotation
  • Easy to read interactive QC reports and performance summaries

Configurations Offered (in Gigabase

[Gb])

8 GbACE Exome for Clinical Research
Comprehensive sequence coverage for clinical research samples.
12 GbACE Exome for Clinical Research
High levels of gene finishing for critical samples.
16 GbACE Exome for Clinical Research
Deep sequencing recommended for analysis of samples where heterogeneity is expected.
Exome DataAnalysis Only
For customers with legacy exome data, we can utilize our advanced variant calling and annotation capabilities to extract the best results from your data.

Personalis® ACE Services for Research Selector

Research Areas
Features Discovery Research Clinical Research Cancer Research
Optimized for Cost-effective variant discovery in large-scale studies Maximum variant detection for every sample Accurate and comprehensive analysis of cancer samples with enhanced coverage of over 1,400 cancer genes
Output (Gigabase [Gb]) 3.5, 5, 6 Gb – average output per samples 8, 12, 16 Gb – minimum output guarantee 8, 16 Gb – minimum output guarantee
Example study types Screening, case control, longitudinal, pedigree Clinical research, FFPE sequencing, and low input DNA studies Tumor only / tumor pairs
Minimum sample committment YES – increments of 24 for fewer than 96 samples NO NO
Analysis included FASTQ, QC, and performance summaries FASTQ, QC, and performance summaries FASTQ, QC, and performance summaries
Additional analysis and annotation Aligned BAM, VCF, and VAR file with more than 40 public and proprietary databases Aligned BAM, VCF, and VAR file with more than 40 public and proprietary databases Cancer-specific analysis and annotation including somatic VAR, VCF, and annotation including COSMIC and Cancer Gene Census