Hugo YK Lam, Cuiping Pan, Michael J Clark, Phil Lacroute, Rui Chen, Rajini Haraksingh, Maeve O’Huallachain, Mark B Gerstein, Jeffrey M Kidd, Carlos D Bustmante, Michael Snyder.
Nature Biotechnology 30, 226-229 (2012) 2012 | doi:10.1038/nbt.2134 Published online 07 March 2012
The DNA sequencing field benefited tremendously from the development of diverse algorithmic approaches at numerous laboratories. Combining these algorithms into a comprehensive pipeline was a challenge taken on by a number of Personalis founders and employees, initially at Stanford. Their work was particularly comprehensive in the areas of structural variation and implementation on highly parallel scientific computing systems, and led to the original version of the widely-adopted HugeSeq pipeline. Personalis has continued this work and now offers a more advanced version of the pipeline to its customers.